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[CAS NO. 197781-85-4] Bonducellpin D
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N2949 |
| Brand: | MCE |
| CAS: | 197781-85-4 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 404.45 |
| Molecular Formula | C22H28O7 |
| SMILES | O[C@]([C@H]1OC(C)=O)(C(C)(CC2)C)[C@@]([C@](CC(OC=C3)=C3[C@]45[H])([H])[C@@]4([H])[C@@]1([H])OC5=O)([C@H]2O)C |
Summary
Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax . Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV M pro and MERS-CoV M pro , with an K i of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro [1] [2] [3] .
IC50 & Target
Ki: 467.11 nM (SARS-CoV Mpro), 284.86 nM (MERS-CoV Mpro) [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
- [1] Gurung AB, et, al. Unravelling lead antiviral phytochemicals for the inhibition of SARS-CoV-2 M pro enzyme through in silico approach. Life Sci. 2020 Aug 15;255:117831.
- [2] Zheng Y, et, al. Caesalminaxins A-L, cassane diterpenoids from the seeds of Caesalpinia minax. J Nat Prod. 2013 Dec 27; 76(12): 2210-8.
- [3] Jiang RW, et, al. Molecular structures and antiviral activities of naturally occurring and modified cassane furanoditerpenoids and friedelane triterpenoids from Caesalpinia minax. Bioorg Med Chem. 2002 Jul;10(7):2161-70.
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