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[CAS NO. 19956-53-7] Lucidone
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-N3364 |
| Brand: | MCE |
| CAS: | 19956-53-7 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 256.25 |
| Molecular Formula | C15H12O4 |
| SMILES | OC(/C=C/C1=CC=CC=C1)=C2C(C(OC)=CC\2=O)=O |
Summary
Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino . Lucidone inhibits LPS-induced NO and PGE 2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) ( EC 50 =25 μM) [1] [2] .
IC50 & Target
|
p38 MAPK
|
JNK
|
p50
|
p65
|
COX-2
|
NF-κB
|
iNOS
|
IKK
|
In Vitro
Lucidone (10 μg/mL, 25 μg/mL; 1 h or 20 h) decreases the increase of TNF-α secretion (20 h) as well as PGE
2
production (1 h) in LPS-induced (1 μg/mL) RAW 264.7 macrophages
[1]
.
Lucidone (10 μg/mL, 25 μg/mL; 8 h) inhibits iNOS and COX-2 expression in LPS-induced (1 μg/mL) RAW 264.7 macrophages
[1]
.
Lucidone (10 μg/mL, 25 μg/mL; 1 h) reduces the levels of p65 and of the p50 subunits of NF-κB, and phosphorylated IKK in LPS-induced (1 μg/mL) RAW 264.7 macrophages
[1]
.
Lucidone (0-40 μM; 3 d) decreases the virus titer of DENV in Huh-7 cells infected with DENV
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | RAW 264.7 macrophages |
| Concentration: | 5 μg/mL, 10 μg/mL, 25 μg/mL |
| Incubation Time: | 1 hour |
| Result: |
Inhibited LPS-induced NF-κB nuclear translocation, decreased the level of p65 and of the p50 subunits at 10 μg/mL and 25 μg/mL.
Inhibited the phosphorylation of IKK at 10 μg/mL and 25 μg/mL. |
Cell Viability Assay [2]
| Cell Line: | Huh-7 cells infected with DENV |
| Concentration: | 5 μM, 10 μM, 20 μM, and 40 μM |
| Incubation Time: | 3 days |
| Result: | Showed no significant cell viability on Huh-7 cells, while leading to a decrease on viral load of DENV. |
In Vivo
Lucidone (1 mg/kg; intracranial injection; 3 times for 1 week) significantly increases the survival rate and body weight of DENV-infected mice [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | DENV-infected ICR mice [2] |
| Dosage: | 0.4 mg/kg, 1 mg/kg |
| Administration: | Intracranial injection; 3 times dose at day 2, 4, 6 after DENV infection |
| Result: | Increased the survival rate and body weight of DENV-infected mice on day 7. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Senthil Kumar KJ, et aL. Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-kappaB and MAPKs signaling pathways. Planta Med. 2009 Apr;75(5):494-500.
- [2] Chen WC, et al. Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1. Virulence. 2018 Jan 1;9(1):588-603.
Synonyms
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