[CAS NO. 200803-37-8] OSIP-486823
PRODUCTS SPECIFICATIONS [200803-37-8]
DESCRIPTION [200803-37-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 473.54 |
| Molecular Formula | C29H28FNO4 |
| SMILES | O=C(NCC1=CC=CC=C1)CC(C2=C/3C=CC(F)=C2)=C(C)C3=C\C4=CC(OC)=C(OC)C(OC)=C4 |
Summary
OSIP-486823 is a novel microtubule -interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules.
IC50 & Target
Microtubule [1]
In Vitro
OSIP486823 inhibits growth and induce apoptosis in SW480 human colon cancer cells, with IC 50 of 0.1 μM. OSIP-486823 (OSIP486823) causes depolymerization of microtubules in interphase cells, inhibit spindle formation in mitotic cells, and induce multinucleated cells. Exisulind and the potent synthetic derivative OSIP-486823 are members of a new class of drugs known as selective apoptotic antineoplastic drugs that target cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE). OSIP-486823 also disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |