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[CAS NO. 20150-34-9] Ferrousbisglycinate
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-130078 |
| Brand: | MCE |
| CAS: | 20150-34-9 |
Overview
| MDL | MFCD07780318 |
|---|---|
| Molecular Weight | 201.95 |
| Molecular Formula | C4H6FeN2O4 |
| SMILES | O=C1[O-][Fe+2]2([O-]C(CN2)=O)NC1 |
Summary
In Vitro
Ferrous bisglycinate (25-200 μM; 2 h) does not affect the Caco-2 cells viability
[2]
.
Ferrous bisglycinate (25 μM; 2 h) increases ferritin content in the Caco-2 cells
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [2]
| Cell Line: | Caco-2 cells |
| Concentration: | 0, 25, 50, 100, 200 μM |
| Incubation Time: | 2 hours |
| Result: | Did not affect the viability of wild-type and divalent metal transporter 1 (DMT1) knockout Caco-2 cells. |
Western Blot Analysis [2]
| Cell Line: | Caco-2 cells |
| Concentration: | 25 μM |
| Incubation Time: | 2 hours |
| Result: | Increased ferritin content and decreased DMT1 expression levels significantly in the wild-type cells. |
In Vivo
Ferrous bisglycinate (500 mg/kg iron; p.o.) exerts a protective effect on colitis in mice [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Female C57BL/6 mice are induced colitis by dextran sodium sulfate (DSS) [3] |
| Dosage: | 500 mg/kg iron |
| Administration: | P.o. (add to the diet) for 10 days |
| Result: |
Had the best survival rates (100%).
Caused the least body lost (9% body loss). |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01160198 | GlaxoSmithKline |
Haematopoiesis
|
October 13, 2010 | Phase 3 |
| NCT03009578 | Assiut University |
Anemia
|
February 1, 2017 | Phase 3 |
| NCT04017598 | University of British Columbia|Helen Keller International|NCHADS - Ministry of Health of Cambodia|BC Children´s Hospital Research Institute|The National Institute of Public Health Laboratory, Phnom Penh |
Anemia, Iron Deficiency|Anemia|Intestinal Inflammation|Inflammation|Intestine; Complaints
|
December 10, 2019 | Phase 4 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
0.1 M HCL : 2 mg/mL ( 9.90 mM ; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.9517 mL | 24.7586 mL | 49.5172 mL |
| 5 mM | 0.9903 mL | 4.9517 mL | 9.9034 mL |
| 10 mM | --- | --- | --- |
-
1.
Add each solvent one by one: PBS
Solubility: 2 mg/mL (9.90 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
References
- [1] Ferrari P, et, al. Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: comparison between oral ferrous bisglycinate chelate and ferrous sulfate. Biomed Pharmacother. 2012 Sep; 66(6): 414-8.
- [2] Yu X, et, al. Iron Transport from Ferrous Bisglycinate and Ferrous Sulfate in DMT1-Knockout Human Intestinal Caco-2 Cells. Nutrients. 2019 Feb 26; 11(3): 485.
- [3] Constante M, et, al. Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfate-induced Colitis. Inflamm Bowel Dis. 2017 May; 23(5): 753-766.
Synonyms
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