[CAS NO. 2070018-33-4] WEHI-539hydrochloride

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PRODUCTS SPECIFICATIONS [2070018-33-4]

Catalog

HY-15607A

Brand

MCE

CAS

2070018-33-4

DESCRIPTION [2070018-33-4]

Overview

MDL	-
Molecular Weight	620.18
Molecular Formula	C31H30ClN5O3S2
SMILES	OC(C1=C(CCCOC2=CC=C(CN)C=C2)SC(C3=CC4=C(CCC/C4=N\NC5=NC(C=CC=C6)=C6S5)C=C3)=N1)=O.[H]Cl

For research use only. We do not sell to patients.

21 Publications Citing Use of MCE

Summary

WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL with an IC ₅₀ of 1.1 nM.

IC50 & Target

Bcl-xL

1.1 nM (IC ₅₀ )

In Vitro

WEHI-539 hydrochloride is a selective inhibitor of Bcl-X _L . WEHI-539 augments NSC 241240 induced caspase 3/7 activity, PARP cleavage and annexin V labelling. WEHI-539 as a single agent causes noticeable PARP cleavage in Ovcar-4 (5 μM in Ovcar-4.) and Ovsaho (1 μM in Ovsaho) cells ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 80.62 mM ; Need ultrasonic)

H ₂ O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6124 mL	8.0622 mL	16.1244 mL
5 mM	0.3225 mL	1.6124 mL	3.2249 mL
10 mM	0.1612 mL	0.8062 mL	1.6124 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.03 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.03 mM); Suspended solution

* All of the co-solvents are available by MCE.