[CAS NO. 207121-48-0] L-Cysteinesulfinic acid monohydrate
PRODUCTS SPECIFICATIONS [207121-48-0]
DESCRIPTION [207121-48-0]
Overview
| MDL | MFCD00150732 |
|---|---|
| Molecular Weight | 171.17 |
| Molecular Formula | C3H9NO5S |
| SMILES | N[C@@H](CS(O)=O)C(O)=O.O |
Summary
IC50 & Target
|
mGluR1 3.92 (pEC 50 ) |
mGluR2 3.9 (pEC 50 ) |
mGluR4 2.7 (pEC 50 ) |
mGluR5 4.6 (pEC 50 ) |
mGluR6 4.0 (pEC 50 ) |
mGluR8 3.94 (pEC 50 ) |
Human Endogenous Metabolite
|
In Vitro
L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC 50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 41.67 mg/mL ( 243.44 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.8421 mL | 29.2107 mL | 58.4215 mL |
| 5 mM | 1.1684 mL | 5.8421 mL | 11.6843 mL |
| 10 mM | 0.5842 mL | 2.9211 mL | 5.8421 mL |
References
- [1] Shi Q, et al. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J Pharmacol Exp Ther. 2003 Apr;305(1):131-42.
- [2] Boss V, et al. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity.