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[CAS NO. 2079056-43-0] PROTACFKBPDegrader-3
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-135345 |
| Brand: | MCE |
| CAS: | 2079056-43-0 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1295.54 |
| Molecular Formula | C68H90N6O17S |
| SMILES | CC[C@H](C(N1[C@H](C(O[C@H](CCC2=CC=C(OC)C(OC)=C2)C3=CC=CC(OCC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4C[C@H](O)C[C@H]4C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O)=C3)=O)CCCC1)=O)C7=CC(OC)=C(OC)C(OC)=C7 |
Summary
IC50 & Target
|
VHL
|
FKBP
|
In Vitro
PROTAC treatment time courses demonstrated a notable increase in polyubiquitination of EGFP-FKBP in response to treatment with 250 nM of PROTAC FKBP Degrader-3 (compound 10) for VHL within the first hour. Upon recruiting endogenous VHL via PROTAC FKBP Degrader-3 (compound 10), only one EGFP background lysine (Lys158) is found to be ubiquitylated [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 25 mg/mL ( 19.30 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.7719 mL | 3.8594 mL | 7.7188 mL |
| 5 mM | 0.1544 mL | 0.7719 mL | 1.5438 mL |
| 10 mM | 0.0772 mL | 0.3859 mL | 0.7719 mL |
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