[CAS NO. 2095515-38-9] RIP1 kinase inhibitor 1
PRODUCTS SPECIFICATIONS [2095515-38-9]
DESCRIPTION [2095515-38-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 461.90 |
| Molecular Formula | C24H20ClN5O3 |
| SMILES | N#CC1=CC=C2N(C)C([C@@H](N3CCC4=C(Cl)N(CC5=CC=CC=C5)N=C4C3=O)COC2=C1)=O |
Summary
RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor ( pK i =9.04) [1] .
IC50 & Target
pKi: 9.04 (RIP1 kinase) [1]
In Vitro
RIP1 kinase inhibitor 1 (compound 22) strongly suppresses necroptotic cell death and phosphorylation of MLKL(pMLKL) in human colorectal adenocarcinoma HT-29 cells (nectoptosis, IC 50 =2 nM; pMLKL, IC 50 =1.3 nM) as well as mouse L-cells NCTC 929 (nectoptosis, IC 50 =15 nM; pMLKL, IC 50 =2.7 nM) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 200 mg/mL ( 432.99 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1650 mL | 10.8249 mL | 21.6497 mL |
| 5 mM | 0.4330 mL | 2.1650 mL | 4.3299 mL |
| 10 mM | 0.2165 mL | 1.0825 mL | 2.1650 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 5 mg/mL (10.82 mM); Clear solution