[CAS NO. 2101739-18-6] RAD51-IN-1
PRODUCTS SPECIFICATIONS [2101739-18-6]
DESCRIPTION [2101739-18-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 373.83 |
| Molecular Formula | C22H16ClN3O |
| SMILES | O=C1N(CC2=CC=C(Cl)C=C2)C(/C=C/C3=CC=CN=C3)=NC4=C1C=CC=C4 |
Summary
In Vitro
RAD51 is a vital component of the homologous recombination DNA repair pathway and is overexpressed in drug-resistant cancers, including aggressive triple-negative breast cancer (TNBC)
[1]
.
RAD51-IN-1 (10 μM) decreases the ratio of RAD51 positive cells/cH2AX positive cells in MDA-MB-231 cell exposure to 6 Gy irradiation
[1]
.
RAD51-IN-1 (10 μM) significantly inhibits DNA damage induced RAD51 foci formation with 6 Gy irradiation
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 167.19 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6750 mL | 13.3751 mL | 26.7501 mL |
| 5 mM | 0.5350 mL | 2.6750 mL | 5.3500 mL |
| 10 mM | 0.2675 mL | 1.3375 mL | 2.6750 mL |
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