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[CAS NO. 2109805-87-8] FEN1-IN-3
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-136484 |
| Brand: | MCE |
| CAS: | 2109805-87-8 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 284.27 |
| Molecular Formula | C15H12N2O4 |
| SMILES | O=C(N1O)N(C2=CC=C(OC)C=C2)C3=C(C=CC=C3)C1=O |
Summary
In Vitro
FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a , both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 879.45 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5178 mL | 17.5889 mL | 35.1778 mL |
| 5 mM | 0.7036 mL | 3.5178 mL | 7.0356 mL |
| 10 mM | 0.3518 mL | 1.7589 mL | 3.5178 mL |
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