[CAS NO. 2127390-15-0] AP1867-3-(aminoethoxy)

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PRODUCTS SPECIFICATIONS [2127390-15-0]

Catelog

HY-129363

Brand

MCE

CAS

2127390-15-0

DESCRIPTION [2127390-15-0]

Overview

MDL	-
Molecular Weight	678.81
Molecular Formula	C38H50N2O9
SMILES	O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCCN)=C3)CCC4=CC=C(OC)C(OC)=C4

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Summary

AP1867-3-(aminoethoxy), the AP1867 based moiety, is a synthetic ligand for FKBP . AP1867-3-(aminoethoxy) can be used in the synthesis of PROTAC FKBP12 F36V degrader ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 240 mg/mL ( 353.56 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4732 mL	7.3658 mL	14.7317 mL
5 mM	0.2946 mL	1.4732 mL	2.9463 mL
10 mM	0.1473 mL	0.7366 mL	1.4732 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 6 mg/mL (8.84 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 6 mg/mL (8.84 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 6 mg/mL (8.84 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Ottis P, et al. Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS Chem Biol. 2017 Oct 20;12(10):2570-2578.