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[CAS NO. 212844-54-7] PurvalanolB
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-18299 |
| Brand: | MCE |
| CAS: | 212844-54-7 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 432.90 |
| Molecular Formula | C20H25ClN6O3 |
| SMILES | O=C(O)C1=CC=C(NC2=C3N=CN(C(C)C)C3=NC(N[C@@H](CO)C(C)C)=N2)C=C1Cl |
1 Publications Citing Use of MCE
Summary
Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK , with IC 50 s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B , CDK2-cyclin A , CDK2-cyclin E and CDK5-p35 , respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC 50 >1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum [1] [1] .
IC50 & Target
|
cdc2/cyclin B 6 nM (IC 50 ) |
cdk2/cyclin A 6 nM (IC 50 ) |
CDK2/cyclinE 9 nM (IC 50 ) |
CDK5/p35 6 nM (IC 50 ) |
In Vitro
Purvalanol B binds to P. falciparum casein kinase 1 (CK1) from blood stage cell lysates and inhibits the growth a chloroquine-resistant strain of P. falciparum (FCR-3) with an IC 50 of 7.07 μM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 40 mg/mL ( 92.40 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3100 mL | 11.5500 mL | 23.1000 mL |
| 5 mM | 0.4620 mL | 2.3100 mL | 4.6200 mL |
| 10 mM | 0.2310 mL | 1.1550 mL | 2.3100 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.78 mM); Clear solution
References
- [1] Gray NS, et, al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8.
- [2] Bullard KM, et, al. Effects of cyclin-dependent kinase inhibitor Purvalanol B application on protein expression and developmental progression in intra-erythrocytic Plasmodium falciparum parasites. Malar J. 2015 Apr 8;14:147.
Synonyms
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