[CAS NO. 2132961-46-5] AZD3458
PRODUCTS SPECIFICATIONS [2132961-46-5]
DESCRIPTION [2132961-46-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 433.54 |
| Molecular Formula | C20H23N3O4S2 |
| SMILES | O=C1N([C@@H](C)C2CC2)CC3=CC(C4=C(C)N=C(NC(C)=O)S4)=CC(S(=O)(C)=O)=C31 |
Summary
IC50 & Target
|
PI3Kγ 9.1 (pIC 50 ) |
PI3Kα 5.1 (pIC 50 ) |
PI3Kβ 4.5 (pIC 50 ) |
PI3Kδ 6.5 (pIC 50 ) |
PI3KC2α 5 (pIC 50 ) |
PI3KC2β 7.5 (pIC 50 ) |
PI3KC2γ 5.5 (pIC 50 ) |
PI3KC3 5.1 (pIC 50 ) |
In Vitro
AZD3458 (Compound 15) also inhibits PI3KC2α, PI3KC2β, PI3KC2γ, and PI3KC3 with pIC 50 s of <5, 7.5, 5.5, and 5.1, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 576.65 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3066 mL | 11.5330 mL | 23.0659 mL |
| 5 mM | 0.4613 mL | 2.3066 mL | 4.6132 mL |
| 10 mM | 0.2307 mL | 1.1533 mL | 2.3066 mL |