[CAS NO. 2140-71-8] 2'-O-Methylguanosine

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PRODUCTS SPECIFICATIONS [2140-71-8]

Catalog

HY-W013260

Brand

MCE

CAS

2140-71-8

DESCRIPTION [2140-71-8]

Overview

MDL	MFCD00057053
Molecular Weight	297.27
Molecular Formula	C11H15N5O5
SMILES	OC[C@@H]1[C@@H](O)[C@@H](OC)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O1

For research use only. We do not sell to patients.

Summary

2'-O-Methylguanosine is a modified nucleoside produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase. 2'-O-Methylguanosine results in apoptotic changes of cells ^[1] ^[2] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 336.39 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3639 mL	16.8197 mL	33.6395 mL
5 mM	0.6728 mL	3.3639 mL	6.7279 mL
10 mM	0.3364 mL	1.6820 mL	3.3639 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.00 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (7.00 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.00 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Guanosine, 2′-O-methyl-

2′-O-Methylguanosine