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[CAS NO. 2146095-85-2] SHIN1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-112066 |
| Brand: | MCE |
| CAS: | 2146095-85-2 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 400.47 |
| Molecular Formula | C24H24N4O2 |
| SMILES | OCC1=CC(C2=CC=CC=C2)=CC(C3(C(C(C)=NN4)=C4OC(N)=C3C#N)C(C)C)=C1 |
4 Publications Citing Use of MCE
Summary
SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 ( SHMT1/2 ) inhibitor with IC 50 s of 5 and 13 nM, respectively, in an in vitro assay.
IC50 & Target
IC50: 5 nM (SHMT1), 13 nM (SHMT1) [1]
In Vitro
SHIN1 (RZ-2994) inhibits human SHIN1 SHMT1/2 with IC 50 s of 5 and 13 nM, respectively in an in vitro assay. SHIN1 inhibits the growth of SHMT2 deletion HCT-116 cells with an IC 50 of 10 nM. SHIN1 (RZ-2994) inhibits SHMT1/2 in HCT-116 cells. SHIN1 (RZ-2994) is particularly active against B-cell malignancies. SHIN1 blocks cell growth through a progressive depletion of purines, leading to loss of nucleotide triphosphates [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 66.67 mg/mL ( 166.48 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4971 mL | 12.4853 mL | 24.9707 mL |
| 5 mM | 0.4994 mL | 2.4971 mL | 4.9941 mL |
| 10 mM | 0.2497 mL | 1.2485 mL | 2.4971 mL |
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