MDL | MFCD00221753 |
---|---|
Molecular Weight | 410.42 |
Molecular Formula | C20H26O9 |
SMILES | O[C@@]1([C@H]2O)[C@@]34[C@@]([C@@H](O)[C@H](O)[C@]1(OC4)C)([H])[C@]([C@@](C(C)=CC5=O)([H])C[C@@]3([H])OC2=O)([C@@H]5O)C |
Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity [1] [2] . Bruceine D has strong anthelmintic activity against D. intermedius with an EC 50 value of 0.57 mg/L [3] .
Notch [1]
Bruceine D inhibits the cell viability of H460 and A549 cells in a dose-dependent manner with IC
50
values of 0.5 and 0.6 μM, respectively, at 48 h of treatment
[1]
.
Bruceine D (0.125-1.0 μM) dose-dependently promotes chromatin condensation, Annexin V-positive cell population and caspase-dependent apoptosis in H460 and A549 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Solid
Room temperature in continental US; may vary elsewhere.
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
DMSO : 100 mg/mL ( 243.65 mM ; Need ultrasonic)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 2.4365 mL | 12.1826 mL | 24.3653 mL |
5 mM | 0.4873 mL | 2.4365 mL | 4.8731 mL |
10 mM | 0.2437 mL | 1.2183 mL | 2.4365 mL |