- Cart - 0 item(s)
- $0.00
Your shopping cart is empty!
- Chemistry
- Inhibitors
- Natural Products
- Alkaloids
- Amino acid
- Anthraquinones
- Cerebrosides
- Chalcones
- Coumarins
- Diterpenoids
- Flavonoids
- Iridoids
- Lignans
- Lipids
- Miscellaneous
- Monoterpenoids
- Other terpenes
- Phenols
- Phenylpropanoids
- Quinones
- Saccharides
- Sesquiterpenoids
- Steroids
- Tetraterpenoids
- Thiophenes
- Triterpenoids
- Xanthones
- Polyphenols
- Stibene glucosides
- Oligose
- Anthocyanins
- Miscellaneous
- Chromones
- Terpenoids
- Indoles
- Procyanidins
- Aliphatics
- Botanical Cyclopeptides
- ADCs
- Antibodies
- Multiplex IHC
- Material Science
- Others
[CAS NO. 2151937-80-1] AVG-233
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-122587 |
| Brand: | MCE |
| CAS: | 2151937-80-1 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 487.94 |
| Molecular Formula | C26H22ClN5O3 |
| SMILES | O=C1N(C2=NC=CC=C2)N(CC3=CC=C(OC)C=C3)C(C1=C(C)N4CC5=NC(Cl)=CC=C5)=CC4=O |
Summary
AVG-233 is a potent, orally active RNA dependent RNA polymerase (RdRp) inhibitor. AVG-233 prevents initiation of the viral polymerase complex at the promoter. AVG-233 binding site is present in the L 1-1749 fragment. AVG-233 has nanomolar activity against both RSV strains and clinical RSV isolates ( EC 50 =0.14-0.31 μM). AVG-233 can be used for research of respiratory syncytial virus (RSV) [1] [2] .
In Vitro
AVG-233 (1-100 μM) blocks 3´RNA extension elongation but does not interfere with 3´RNA extension by up to three nucleotides after de novo initiation from the promoter or back-priming
[1]
.
AVG-233 (20 μM) reduces virus yield of RSV A2-L19F (EC
50
=0.31 μM), RSV strain 2-20 (EC
50
=0.14 μM) and RSV clinical isolate 718 (EC
50
=0.2 μM)
[1]
.
AVG-233 (1.25-40 μM; 0-300 s) suppresses RNA synthesis by the L1-1749 fragment in a dose-dependent manner with an IC
50
value of 13.7 μM. AVG-233 bounds L and the L
1-1749
fragment with similar affinities (dissociation constants (KD’s) are 38.3 μM and 53.1 μM, respectively)
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
AVG-233 (50-100 mg/kg; i.g.; once) decreases lung viral load in the RSV mouse model
[2]
.
AVG-233 (2-20 mg/kg; i.v. and p.o.; once; male CD-1 mice) has good orally bioavailable and the maximum plasma concentration about 2 μM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Female Balb/cJ mice with recRSV-mKate xenograft [2] |
| Dosage: | 50 and 100 mg/kg |
| Administration: | Oral gavage; once |
| Result: | Reduced in lung viral load of 0.89 log 10 TCID 50 (median tissue culture infectious dose)/mL. |
| Animal Model: | Male CD-1 mice (27-29 g) [1] | ||||||||||||||||||||||||
| Dosage: | 2 mg/kg (i.v.) and 20 mg/kg (p.o.) | ||||||||||||||||||||||||
| Administration: | Intravenous injection and oral administration; once, obtains blood samples at pre-dose and 0.083, 0.25, 0.5, 1, 2, 4, 8, and 24 h post-dosing | ||||||||||||||||||||||||
| Result: |
|
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
References
- [1] Cox RM, et, al. Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex. J Biol Chem. 2018 Oct 26;293(43):16761-16777.
- [2] Sourimant J, et, al. Orally efficacious lead of the AVG inhibitor series targeting a dynamic interface in the respiratory syncytial virus polymerase. Sci Adv. 2022 Jun 24;8(25):eabo2236.
Arctom is a premier supply platform offering over 600K unique items of Building Blocks, Bioactive Molecules, Natural Products, ADC PEG Linkers, Antibodies, and other Research Chemicals for global pharmaceutical, biotech, university, and industrial customers. We accelerate your research by providing better and faster purchasing experience & services.