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[CAS NO. 2156-56-1] Sodium dichloroacetate
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-Y0445A |
| Brand: | MCE |
| CAS: | 2156-56-1 |
Overview
| MDL | MFCD00070489 |
|---|---|
| Molecular Weight | 150.92 |
| Molecular Formula | C2HCl2NaO2 |
| SMILES | O=C(O[Na])C(Cl)Cl |
10 Publications Citing Use of MCE
- [1]Signal Transduct Target Ther. 2022 Sep 1;7(1):303.
- [2]Life Sciences. 2022: 121192.
- [3]Cell Death Dis. 2021 Sep 6;12(9):837.
- [4]Cancers (Basel). 2022 Oct 10;14(19):4966.
- [5]Oxid Med Cell Longev. 2021 Jun 27;2021:5549047.
- [6]Oxid Med Cell Longev. 2021 Jun 4.
- [7]J Biol Chem. 4 March 2022, 101775.
- [8]Exp Cell Res. 2021 Jul 29;112755.
- [9]Mol Reprod Dev. 2021 May 25.
- [10]Cancer Drug Resist. 2020 Sep 12.
Summary
Sodium dichloroacetate is a metabolic regulator in cancer cells' mitochondria with anticancer activity. Sodium dichloroacetate inhibits PDHK , resulting in decreased lactic acid in the tumor microenvironment. Sodium dichloroacetate increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis . Sodium dichloroacetate also works as NKCC inhibitor [1] .
IC50 & Target
PDHK; Reactive oxygen species (ROS); Apoptosis; NKCC [1]
In Vitro
Sodium dichloroacetate increases ROS generation in mitochondria. Sodium dichloroacetate affects cell growth and viability through the ROS production increase derived from the promotion of oxidative metabolism. The effects of Sodium dichloroacetate on multiple myeloma cell viability, cell cycle arrest, and apoptotic cell death were associated with pyruvate dehydrogenase kinases (PDK) inhibition, restored pyruvate dehydrogenase (PDH) activity, and the promotion of oxidative metabolism in association with increased intracellular ROS production which depends on the Sodium dichloroacetate dose. The Sodium dichloroacetate effects cooperated with C I inhibition promoting the oxidative stress in rat VM-M3 glioblastoma cells. Increased ROS levels in Sodium dichloroacetate-treated cancer cells are related to the induction of apoptosis associated with the increased cytochrome c expression. Sodium dichloroacetate causes ROS-dependent T-cell differentiation [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
The NKCC1 RNA expression levels in Sodium dichloroacetate-treated gonad-intact and castrated males are significantly decreased, and no such effect is determined in the gonad-intact and castrated female Sodium dichloroacetate-treated rats
[1]
.
A single Sodium dichloroacetate dose causes a significantly higher 24 h diuresis in Wistar male rats, and the increased diuresis is related to NKCC2 inhibition. The NKCC2 is more abundant in kidneys of intact females compared to intact males, with a greater transporter density in Sprague-Dawley female rats
[1]
.
The oral Sodium dichloroacetate bioavailability in naïve male rats dosed 5, 20 and 100 mg/kg is significantly lower than in GSTζ-depleted ones (10%, 13%, 81% and 31%, 75%, 100%, respectively). The liver extraction of Sodium dichloroacetate in the GSTζ-depleted rats has linear kinetics, but it decreases with the metabolism saturation at higher doses
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00004493 | University of California, San Diego|FDA Office of Orphan Products Development |
Lactic Acidosis
|
September 1998 | Phase 2 |
| NCT00004490 | University of Florida|FDA Office of Orphan Products Development |
Lactic Acidosis
|
October 1998 | Phase 3 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL ( 662.60 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.6260 mL | 33.1301 mL | 66.2603 mL |
| 5 mM | 1.3252 mL | 6.6260 mL | 13.2521 mL |
| 10 mM | 0.6626 mL | 3.3130 mL | 6.6260 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (662.60 mM); Clear solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.25 mg/mL (14.91 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.25 mg/mL (14.91 mM); Clear solution
Synonyms
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