[CAS NO. 2169-64-4] Azaribine

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PRODUCTS SPECIFICATIONS [2169-64-4]

Catalog

HY-B1537

Brand

MCE

CAS

2169-64-4

DESCRIPTION [2169-64-4]

Overview

MDL	-
Molecular Weight	371.30
Molecular Formula	C14H17N3O9
SMILES	CC(OC[C@@H]1[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](N2N=CC(NC2=O)=O)O1)=O

For research use only. We do not sell to patients.

Summary

Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity ( EC ₅₀ =3.80 nM-1.73 μM against influenza A and B viruses; EC ₅₀ =1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research ^[1] ^[2] .

In Vitro

Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine; 0-2 μM; 48 h) has cytotoxicity on MDCK cells (MTT: CC ₅₀ =19.66 μM) ^[1] .
Azaribine shows a potent inhibitory effect on BIRFLU multiplication (MDCK cells: EC ₅₀ =0.29 μM; A549 cells: EC ₅₀ =0.55 μM) ^[1] .
Azaribine shows against seasonal H1N1 and H3N2 IAVs and IBV during posttreatment in MDCK cells with EC ₅₀ of 0.60 μM, 0.77 μM, 0.80 μM ^[1] .
Azaribine is against NC H1N1 during posttreatment in 16HBE cells (EC ₅₀ =1.58 μM) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay ^[1]

Cell Line:	MDCK cells
Concentration:	0-2 μM
Incubation Time:	48 h
Result:	Had cytotoxicity on MDCK cells (CC ₅₀ =19.66 μM).

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

Synonyms

1,2,4-Triazine-3,5(2H,4H)-dione, 2-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-

as-Triazine-3,5(2H,4H)-dione, 2-β-D-ribofuranosyl-, 2′,3′,5′-triacetate

2-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione

CB 304

Azaribine

Triazure

2′,3′,5′-Tri-O-acetyl-6-azauridine

6-Azauridine triacetate

Azaribin

6-Aza-2′,3′,5′-tri-O-acetyluridine

NSC 67239