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[CAS NO. 2169-64-4] Azaribine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B1537 |
| Brand: | MCE |
| CAS: | 2169-64-4 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 371.30 |
| Molecular Formula | C14H17N3O9 |
| SMILES | CC(OC[C@@H]1[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](N2N=CC(NC2=O)=O)O1)=O |
Summary
Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity ( EC 50 =3.80 nM-1.73 μM against influenza A and B viruses; EC 50 =1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research [1] [2] .
In Vitro
Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine; 0-2 μM; 48 h) has cytotoxicity on MDCK cells (MTT: CC
50
=19.66 μM)
[1]
.
Azaribine shows a potent inhibitory effect on BIRFLU multiplication (MDCK cells: EC
50
=0.29 μM; A549 cells: EC
50
=0.55 μM)
[1]
.
Azaribine shows against seasonal H1N1 and H3N2 IAVs and IBV during posttreatment in MDCK cells with EC
50
of 0.60 μM, 0.77 μM, 0.80 μM
[1]
.
Azaribine is against NC H1N1 during posttreatment in 16HBE cells (EC
50
=1.58 μM)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Cytotoxicity Assay [1]
| Cell Line: | MDCK cells |
| Concentration: | 0-2 μM |
| Incubation Time: | 48 h |
| Result: | Had cytotoxicity on MDCK cells (CC 50 =19.66 μM). |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Jun-Gyu Park, et al. Identification and Characterization of Novel Compounds with Broad-Spectrum Antiviral Activity against Influenza A and B Viruses. J Virol. 2020 Mar 17;94(7):e02149-19.
- [2] Desarey Morales Vasquez, et al. Identification of Inhibitors of ZIKV Replication. Viruses. 2020 Sep 18;12(9):1041.
Synonyms
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