[CAS NO. 2170170-27-9] SOD1-Derlin-1 inhibitor-2
PRODUCTS SPECIFICATIONS [2170170-27-9]
DESCRIPTION [2170170-27-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 386.47 |
| Molecular Formula | C22H18N4OS |
| SMILES | O=C(C1=C(N)C2=CC=C(C3=CC=CN=C3)N=C2S1)N(C4=CC=CC=C4)CC=C |
Summary
SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1 mut . SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS) [1] .
In Vitro
SOD1-Derlin-1 inhibitor-2 (compound 56-59; 0.1-100 μM) inhibits the SOD1-Derlin-1 interaction in a dose-dependent manner [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
SOD1-Derlin-1 inhibitor-2 (compound 56-59; i.c.v.; 3 mM, flow rate 0.15 μL/h) ameliorates ALS pathology in ALS model mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | ALS model C57BL/6 mice [1] |
| Dosage: | 3 mM, flow rate 0.15 μL/h |
| Administration: | intracerebroventrical injection |
| Result: | Had significantly delayed onset, by a median of 4.5 weeks (14.5% improvement) and prolonged survival, by a median of 5 weeks (14.2% improvement). |
Shipping
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.