[CAS NO. 2170696-76-9] LysRs-IN-2
PRODUCTS SPECIFICATIONS [2170696-76-9]
DESCRIPTION [2170696-76-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 355.31 |
| Molecular Formula | C17H16F3NO4 |
| SMILES | FC1=CC=C(OC(C(NCC2(O)CCC(F)(F)CC2)=O)=CC3=O)C3=C1 |
Summary
LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC 50 s of 0.015 μM and 0.13 μM for Plasmodium falciparum lysyl-tRNA synthetase ( Pf KRS) and Cryptosporidium parvum lysyl-tRNA synthetase ( Cp KRS), respectively [1] .
IC50 & Target
IC50: 0.015 μM ( Pf KRS), 0.13 μM ( Cp KRS) [1]
In Vitro
LysRs-IN-2 is active against whole-cell bloodstream P. falciparum 3D7 (EC 50 =0.27 μM), Hs KRS (IC 50 =1.8 μM), HepG2 cells (EC 50 =49 μM), and Cryptosporidium parvum (EC 50 =2.5 µM) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
LysRs-IN-2 (1.5 mg/kg; orally once a day for 4 days) reduces parasitemia by 90% in the murine P. falciparum SCID model. LysRs-IN-2 (20 mg/kg; orally once a day for 7 days) reduces parasite shedding in NOD SCID gamma mice and INF-γ-knockout mice ( Cryptosporidium mouse models) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Murine P. falciparum NODscidIL2Rγnull (SCID) model [1] |
| Dosage: | 1.5 mg/kg |
| Administration: | Orally once a day for 4 days |
| Result: | Reduced parasitemia by 90% in the malaria SCID mouse model. |
| Animal Model: | NOD SCID gamma and INF-γ–knockout mouse models ( Cryptosporidium mouse models) [1] |
| Dosage: | 20 mg/kg |
| Administration: | Orally once a day for 7 days |
| Result: | Reduced parasite shedding below detection level, and this reduction was sustained for 3 wk after treatment had stopped in INF-γ-knockout mice. Dosed orally at a concentration of 20 mg/kg once a day for 7 days showed 96% reduction of parasite shedding comparable to paromomycin in NOD SCID gamma mice. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 60 mg/mL ( 168.87 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8144 mL | 14.0722 mL | 28.1444 mL |
| 5 mM | 0.5629 mL | 2.8144 mL | 5.6289 mL |
| 10 mM | 0.2814 mL | 1.4072 mL | 2.8144 mL |