[CAS NO. 2172617-15-9] YKL-06-061
PRODUCTS SPECIFICATIONS [2172617-15-9]
DESCRIPTION [2172617-15-9]
Overview
| MDL | MFCD32173438 |
|---|---|
| Molecular Weight | 527.66 |
| Molecular Formula | C30H37N7O2 |
| SMILES | O=C1N(C2=NC(NC3=CC=C(C=C3OC)N4CCN(CC4)C)=NC=C2CN1C5=C(C=CC=C5C)C)C6CCC6 |
2 Publications Citing Use of MCE
Summary
YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC 50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively [1] .
IC50 & Target
IC50: 6.56 nM/1.77 nM/20.5 nM (SIK1/2/3) [1] .
In Vitro
YKL 06-061 yields a dose-dependent increase in MITF mRNA expression [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
RT-PCR [1]
| Cell Line: | UACC62 human melanoma cells, and UACC257 human melanoma cells. |
| Concentration: | 0-4 μM (UACC62); 0-16 μM (UACC257). |
| Incubation Time: | 3 hours. |
| Result: | Yielded a dose-dependent increase in MITF mRNA expression. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 16.67 mg/mL ( 31.59 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8952 mL | 9.4758 mL | 18.9516 mL |
| 5 mM | 0.3790 mL | 1.8952 mL | 3.7903 mL |
| 10 mM | 0.1895 mL | 0.9476 mL | 1.8952 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 1.25 mg/mL (2.37 mM); Clear solution