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[CAS NO. 221243-82-9] 1-NaphthylPP1

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Catalog:	HY-13941
Brand:	MCE
CAS:	221243-82-9

Overview

MDL	MFCD03425471
Molecular Weight	317.39
Molecular Formula	C19H19N5
SMILES	CC(N1N=C(C2=C3C=CC=CC3=CC=C2)C4=C(N)N=CN=C41)(C)C

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Plant J. 2019 Mar;97(5):970-983.

Summary

1-Naphthyl PP1 (1-NA-PP 1) is a selective inhibitor of src family kinases. 1-Naphthyl PP1 inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC ₅₀ s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL ( 39.38 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1507 mL	15.7535 mL	31.5070 mL
5 mM	0.6301 mL	3.1507 mL	6.3014 mL
10 mM	0.3151 mL	1.5753 mL	3.1507 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1.25 mg/mL (3.94 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.25 mg/mL (3.94 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Bishop AC, et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21;407(6802):395-401.
[2] Tandon M, et al. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. PLoS One. 2013 Sep 23;8(9):e75601.

Synonyms

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-

1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-NA-PP 1

1-Naphthyl PP 1

1-tert-Butyl-3-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-4-amine

PP1 analog

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