[CAS NO. 2226201-97-2] KSC-34
PRODUCTS SPECIFICATIONS [2226201-97-2]
DESCRIPTION [2226201-97-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 429.95 |
| Molecular Formula | C21H28ClN7O |
| SMILES | O=C(NCCNC1=NC(N(C)CCCCC2=CC=CC=C2)=NC(NCC#C)=N1)CCl |
Summary
KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1) , is also a selective and potent a-site inhibitor of PDIA1 with an IC 50 of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family [1] .
IC50 & Target
IC50: 3.5 μM (a active site of PDIA1), 104.5 μM (a′ active site of PDIA1) [1]
In Vitro
KSC-34 is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins. KSC-34 contains a (4-phenylbutyl)methylamine diversity element for optimized binding to the active site of the a domain of PDIA1 with a chloroacetamide electrophile for covalent modification of C53 on PDIA1 [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL ( 232.59 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3259 mL | 11.6293 mL | 23.2585 mL |
| 5 mM | 0.4652 mL | 2.3259 mL | 4.6517 mL |
| 10 mM | 0.2326 mL | 1.1629 mL | 2.3259 mL |