[CAS NO. 2227110-54-3] 3-IN-PP1
PRODUCTS SPECIFICATIONS [2227110-54-3]
DESCRIPTION [2227110-54-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 306.37 |
| Molecular Formula | C17H18N6 |
| SMILES | NC1=C2C(N(C(C)(C)C)N=C2C3=CNC4=C3C=CC=C4)=NC=N1 |
Summary
3-IN-PP1 is a protein kinase D (PKD) inhibitor. 3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1 , PKD2 and PKD3 with IC 50 values of 108, 94 and 108 nM, respectively. 3-IN-PP1 also is a broad spectrum anticancer agent and has inhibition of several tumor cells growth. 3-IN-PP1 can be used for the research of cancer [1] .
IC50 & Target
|
PKD1 108 nM (IC 50 ) |
Cellular PKD2 94 nM (IC 50 ) |
PKD3 108 nM (IC 50 ) |
In Vitro
3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1, PKD2 and PKD3 with IC
50
values of 108, 94 and 108 nM, respectively
[1]
.
3-IN-PP1 (5 μM, 0-114 h) displays potent anti-proliferative activity against PANC-1 cells
[1]
.
3-IN-PP1 (20 μM, 1 h) potently blocks PKD-dependent cortactin phosphorylation in PANC-1 cells
[1]
.
3-IN-PP1 has inhibition of different tumor cell growth with IC
50
values range from 1.6 to 39.2μM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | PANC-1 cell |
| Concentration: | 5 μM |
| Incubation Time: | 0-114 h |
| Result: | Significantly inhibited PANC-1 cell proliferation after incubation for 96 and 144 hours. |
Western Blot Analysis [1]
| Cell Line: | PANC-1 cells |
| Concentration: | 20 μM |
| Incubation Time: | 1 h |
| Result: | Reduced cortactin phosphorylation in PANC-1 cells. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL ( 326.40 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2640 mL | 16.3201 mL | 32.6403 mL |
| 5 mM | 0.6528 mL | 3.2640 mL | 6.5281 mL |
| 10 mM | 0.3264 mL | 1.6320 mL | 3.2640 mL |