[CAS NO. 2227149-22-4] DS18561882
PRODUCTS SPECIFICATIONS [2227149-22-4]
DESCRIPTION [2227149-22-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 608.63 |
| Molecular Formula | C28H31F3N4O6S |
| SMILES | CS(=O)(NC1=CC=C(C(N2CCC(C3=CC=C(N4C[C@H](C)N(C)CC4)C(C)=C3O5)=C(C5=O)C2)=O)C=C1OC(F)(F)F)=O |
6 Publications Citing Use of MCE
Summary
DS18561882 is a highly potent, isozyme-selective methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor with an IC 50 value of 0.0063 μM. DS18561882 also has inhibitory effect on MTHFD1 ( IC 50 =0.57 μM). DS18561882 exhibits a good oral pharmacokinetic profile [1] .
IC50 & Target
IC50: 0.0063 μM (MTHFD2); 0.57 μM (MTHFD1) [1]
In Vitro
DS18561882 (0-150 nM) gives the lowest
GI
50
value (140 nM) against the MDA-MB-231 cell line
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
DS18561882 (oral administration; 30, 100 or 300 mg/kg; twice daily) inhibits tumor growth inhibition with a dose-dependent manner, the tumor is completely inhibited (TGI: 67%) at the dose of 300 mg/kg in mice
[1]
.
DS18561882 (oral administration; 10, 30, 100, or 300 mg/kg) has a good oral pharmacokinetic profile, including ACU (64.6, 264, 726 μg.h/ml ); C
max
(11.4, 56.5, 90.1 μg/ml); t
1/2
(2.21, 2.16, 2.32 hours) for 30 mg/kg; 100mg/kg; 200 mg/kg, respectively
[1]
.
DS18561882 is suspended in a 0.5% (w/v) methyl cellulose 400 solution in this article
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Five week old female BALB/cAJcl-nu/nu mice with MDA-MB-231 luc tumor cells (4 × 10 6 cells/mouse) [1] |
| Dosage: | 30, 100 or 300 mg/kg |
| Administration: | Oral administration; 30, 100 or 300 mg/kg; twice daily; until day 11 |
| Result: | Suppressed tumor growth in a dose-dependent manner. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 150 mg/mL ( 246.46 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.6430 mL | 8.2152 mL | 16.4303 mL |
| 5 mM | 0.3286 mL | 1.6430 mL | 3.2861 mL |
| 10 mM | 0.1643 mL | 0.8215 mL | 1.6430 mL |