[CAS NO. 2230911-59-6] INCB086550

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PRODUCTS SPECIFICATIONS [2230911-59-6]

Catalog

HY-134884

Brand

MCE

CAS

2230911-59-6

MDL	-
Molecular Weight	693.79
Molecular Formula	C41H39N7O4
SMILES	N#CC1=C2C(N=C(C3=C(C(C4=C(C(NC5=NC=CC6=C5N=CC(CN7CC[C@H](C7)O)=C6)=CC=C4)C)=CC=C3)C)O2)=CC(CN8C[C@@H](CC8)C(O)=O)=C1

For research use only. We do not sell to patients.

INCB086550 (PD-1/PD-L1-IN-8; example 24) is a PD-1/PD-L1 inhibitor, with an IC ₅₀ <= 10 nM ^[1] .

NCT Number	Sponsor	Condition	Start Date	Phase
NCT04674748	Incyte Biosciences Japan GK\|Incyte Corporation	Solid Tumors	February 3, 2021	Phase 1
NCT04629339	Incyte Corporation	Non Small Cell Lung Cancer\|Urothelial Cancer\|Renal Cell Carcinoma\|Hepatocellular Carcinoma\|Melanoma	September 2, 2021	Phase 2
NCT03762447	Incyte Corporation	Solid Tumors	December 10, 2018	Phase 1
NCT05101369	Incyte Corporation	Healthy Volunteers	January 21, 2022	Phase 1

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

H ₂ O : 83.33 mg/mL ( 120.11 mM ; ultrasonic and adjust pH to 3 with HCl)

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Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.