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[CAS NO. 223104-29-8] SEA0400
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-15515 |
| Brand: | MCE |
| CAS: | 223104-29-8 |
Overview
| MDL | MFCD07772188 |
|---|---|
| Molecular Weight | 371.38 |
| Molecular Formula | C21H19F2NO3 |
| SMILES | NC1=CC(OCC)=CC=C1OC2=CC=C(OCC3=CC(F)=CC=C3F)C=C2 |
14 Publications Citing Use of MCE
- [1]J Clin Invest. 2016 Jan;126(1):112-22.
- [2]Autophagy. 2021 Nov;17(11):3592-3606.
- [3]JCI Insight. 2019 Apr 25;5(11):e128765.
- [4]Cell Calcium. 2016 Jul;60(1):25-31.
- [5]J Physiol. 2015 Aug 1;593(15):3333-50.
- [6]J Physiol. 2015 Mar 15;593(6):1459-77.
- [7]J Physiol. 2014 Nov 15;592(Pt 22):4969-93.
- [8]Cells. 2019 Dec 31;9(1):102.
- [9]Cell Signal. 2017 May 20;37:12-30.
- [10]Am J Physiol Heart Circ Physiol. 2016 Dec 1;311(6):H1352-H1359.
- [11]Pflugers Arch. 2015 Oct;467(10):2151-63.
- [12]Brain Res. 2016 Aug 1;1644:249-57.
- [13]Biochem Biophys Rep. 2017 Jan 11;9:245-256.
- [14]JACC Basic Transl Sci. 2016 Jun;1(4):251-266.
Summary
SEA0400 is a novel and selective inhibitor of the Na + -Ca 2+ exchanger ( NCX ), inhibiting Na + -dependent Ca 2+ uptake in cultured neurons, astrocytes, and microglia with IC 50 s of from 5 to 33 nM.
IC50 & Target
IC50: 5-33 nM (NCX)
In Vitro
SEA0400 inhibits Na + -dependent 45 Ca 2+ uptake in cultured neurons, astrocytes, and microglia. IC 50 values of SEA0400 are 33 nM (neurons), 5.0 nM (astrocytes), and 8.3 nM (microglia) [1] . SEA0400 prevents sodium nitroprusside (SNP) to increase ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca 2+ -dependent manner [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
SEA0400 (3 mg/kg + 3 mg/kg/h for 2 h, i.v.) attenuates the infarct volume in the cerebral cortex and striatum, does not affect the mean the regional cortical blood flow in anesthetized rats [1] . SEA0400 protects against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated C57BL/6J mice [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 32 mg/mL ( 86.17 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6927 mL | 13.4633 mL | 26.9266 mL |
| 5 mM | 0.5385 mL | 2.6927 mL | 5.3853 mL |
| 10 mM | 0.2693 mL | 1.3463 mL | 2.6927 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (6.73 mM); Clear solution
References
- [1] Matsuda T, et al. SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J Pharmacol Exp Ther. 2001 Jul;298(1):249-56.
- [2] Nashida T, et al. The specific Na(+)/Ca(2+) exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells. Neurochem Int. 2011 Aug;59(1):51-8.
- [3] Ago Y, et al. SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease. Neuropharmacology. 2011 Dec;61(8):1441-51.
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