[CAS NO. 2237925-62-9] DMA-135hydrochloride
PRODUCTS SPECIFICATIONS [2237925-62-9]
DESCRIPTION [2237925-62-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 359.81 |
| Molecular Formula | C16H18ClN7O |
| SMILES | O=C(C1=NC(C#CC2=CC=CC=C2)=C(N(C)C)N=C1N)NC(N)=N.Cl |
Summary
DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (K D = 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL ( 138.96 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7792 mL | 13.8962 mL | 27.7924 mL |
| 5 mM | 0.5558 mL | 2.7792 mL | 5.5585 mL |
| 10 mM | 0.2779 mL | 1.3896 mL | 2.7792 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 5 mg/mL (13.90 mM); Clear solution