[CAS NO. 2245072-21-1] LIT-001
PRODUCTS SPECIFICATIONS [2245072-21-1]
DESCRIPTION [2245072-21-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 645.70 |
| Molecular Formula | C30H34F3N7O4S |
| SMILES | O=C(N1[C@H](C(N(C)C)=S)CCC1)NCC2=CC=C(C(N3C4=CC=CC=C4NC(N(C)N=C5)=C5C3)=O)C=C2C.O=C(O)C(F)(F)F |
Summary
LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist ( EC 50 =55 nM; K i =226 nM). LIT-001 improves social interaction in a mouse model of autism [1] .
In Vitro
In vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD ) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Oprm1 –/– mice (bred in house on a 50% 129SVPas–50% C57BL/6J hybrid background) [1] |
| Dosage: | 10, 20 mg/kg |
| Administration: | i.p. |
| Result: | Alleviated core symptoms in the context of ASD. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL ( 154.87 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5487 mL | 7.7435 mL | 15.4871 mL |
| 5 mM | 0.3097 mL | 1.5487 mL | 3.0974 mL |
| 10 mM | 0.1549 mL | 0.7744 mL | 1.5487 mL |