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[CAS NO. 2247894-32-0] SGC-AAK1-1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-123940 |
| Brand: | MCE |
| CAS: | 2247894-32-0 |
Overview
| MDL | MFCD31689256 |
|---|---|
| Molecular Weight | 427.52 |
| Molecular Formula | C21H25N5O3S |
| SMILES | O=C(C1CC1)NC2=NNC3=C2C=CC(C4=CC=CC(NS(=O)(N(CC)CC)=O)=C4)=C3 |
Summary
In Vitro
SGC-AAK1-1 (1.25 μM) significantly reduces phosphorylation of AP2M1 (T156) and activates WNT-driven BAR activity compared in a dose-dependent manner in HT1080 cells
[1]
.
SGC-AAK1-1 blocks AAK1 kinase activity, resulting in increased β-catenin protein stability and β-catenin-dependent transcription
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 116.95 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3391 mL | 11.6954 mL | 23.3907 mL |
| 5 mM | 0.4678 mL | 2.3391 mL | 4.6781 mL |
| 10 mM | 0.2339 mL | 1.1695 mL | 2.3391 mL |
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1.
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