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Catalog: | HY-126010 |
Brand: | MCE |
CAS: | 2253744-54-4 |
MDL | MFCD32174346 |
---|---|
Molecular Weight | 326.20 |
Molecular Formula | C13H9Cl2N3OS |
SMILES | ClC1=C(C(Cl)=CC=C1)CSC2=NN=C(C3=CC=CN3)O2 |
Dooku1, an analog of Yoda1, is a selective antagonist of the endogenous Piezo1 channel . Dooku1 inhibited 2 μM Yoda1-induced Ca 2+ -entry with IC 50 values of 1.3 μM (in HEK 293 cells) and 1.5 μM (in HUVECs). Dooku1 inhibits Yoda1-induced relaxation of aorta [1] .
Solid
Room temperature in continental US; may vary elsewhere.
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
DMSO : 100 mg/mL ( 306.56 mM ; Need ultrasonic)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 3.0656 mL | 15.3280 mL | 30.6560 mL |
5 mM | 0.6131 mL | 3.0656 mL | 6.1312 mL |
10 mM | 0.3066 mL | 1.5328 mL | 3.0656 mL |
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (6.38 mM); Clear solution
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