[CAS NO. 2253744-54-4]  Dooku1

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PRODUCTS SPECIFICATIONS [2253744-54-4]

Catalog
HY-126010
Brand
MCE
CAS
2253744-54-4

DESCRIPTION [2253744-54-4]

Overview

MDLMFCD32174346
Molecular Weight326.20
Molecular FormulaC13H9Cl2N3OS
SMILESClC1=C(C(Cl)=CC=C1)CSC2=NN=C(C3=CC=CN3)O2

For research use only. We do not sell to patients.


Summary

Dooku1, an analog of Yoda1, is a selective antagonist of the endogenous Piezo1 channel . Dooku1 inhibited 2 μM Yoda1-induced Ca 2+ -entry with IC 50 values of 1.3 μM (in HEK 293 cells) and 1.5 μM (in HUVECs). Dooku1 inhibits Yoda1-induced relaxation of aorta [1] .


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)


Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 306.56 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0656 mL 15.3280 mL 30.6560 mL
5 mM 0.6131 mL 3.0656 mL 6.1312 mL
10 mM 0.3066 mL 1.5328 mL 3.0656 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.38 mM); Clear solution

* All of the co-solvents are available by MCE.