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[CAS NO. 2260791-14-6] OSMI-4
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-114361 |
| Brand: | MCE |
| CAS: | 2260791-14-6 |
Overview
| MDL | MFCD31813742 |
|---|---|
| Molecular Weight | 604.09 |
| Molecular Formula | C27H26ClN3O7S2 |
| SMILES | O=C1C=CC2=C(C=C(Cl)C(S(N[C@@H](C(N(CC(OCC)=O)CC3=CC=CS3)=O)C4=C(OC)C=CC=C4)(=O)=O)=C2)N1 |
9 Publications Citing Use of MCE
- [1]Acta Biomater. 2022 Aug 21;S1742-7061(22)00509-8.
- [2]J Biomed Sci. 2022 Feb 14;29(1):13.
- [3]RNA Biol. 2021 Sep 30;1-8.
- [4]J Biol Chem. 2022 Aug 2;102340.
- [5]Glycobiology. 2022 Jun 16;cwac038.
- [6]J Cancer Res Clin Oncol. 2022 Nov 18.
- [7]Exp Biol Med. 2022 Jun 20;15353702221101810.
- [8]Burns Trauma. 08 October 2021.
- [9]bioRxiv. 2023 Jan 11.
Summary
OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC 50 of 3 μM in cells.
IC50 & Target
EC50: 3 μM (OGT) [1] .
In Vitro
OSMI-4 (4b) is the best OGT inhibitor reported to date, with a ∼3 μM EC 50 in cells, making it especially attractive for probing OGT’s complex biology [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 103.46 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.6554 mL | 8.2769 mL | 16.5538 mL |
| 5 mM | 0.3311 mL | 1.6554 mL | 3.3108 mL |
| 10 mM | 0.1655 mL | 0.8277 mL | 1.6554 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (3.44 mM); Clear solution
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