[CAS NO. 2285446-67-3] (E/Z)-E64FC26

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PRODUCTS SPECIFICATIONS [2285446-67-3]

Catalog

HY-122895A

Brand

MCE

CAS

2285446-67-3

DESCRIPTION [2285446-67-3]

Overview

MDL	-
Molecular Weight	340.38
Molecular Formula	C19H23F3O2
SMILES	OC1=CC2=C(/C(C=C2C(F)(F)F)=C/CCCCCCCC)C=C1O

For research use only. We do not sell to patients.

Summary

(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC ₅₀ s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity ^[1] ^[2] .

IC50 & Target

PDI, Apoptosis ^[1] ^[2]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 293.79 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9379 mL	14.6895 mL	29.3789 mL
5 mM	0.5876 mL	2.9379 mL	5.8758 mL
10 mM	0.2938 mL	1.4689 mL	2.9379 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (7.34 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.