[CAS NO. 229002-10-2] MAPK13-IN-1

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PRODUCTS SPECIFICATIONS [229002-10-2]

Catalog

HY-18850

Brand

MCE

CAS

229002-10-2

DESCRIPTION [229002-10-2]

Overview

MDL	MFCD30533529
Molecular Weight	365.43
Molecular Formula	C20H23N5O2
SMILES	O=C(NC1=CC=C(OC2=CC=NC=C2)C=C1)NC3=CC(C(C)(C)C)=NN3C

For research use only. We do not sell to patients.

3 Publications Citing Use of MCE

Summary

MPAK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC ₅₀ of 620 nM.

IC50 & Target

MAPK13 (p38δ)

620 nM (IC ₅₀ )

In Vitro

MPAK13-IN-1 exhibits an IC ₅₀ of 4.63 μM in vero E6 cells ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[2]

Cell Line:	Vero E6 cells ^[2] .
Concentration:	0-100 μM.
Incubation Time:
Result:	Exhibited an IC ₅₀ of 4.63 μM.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 250 mg/mL ( 684.13 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7365 mL	13.6825 mL	27.3650 mL
5 mM	0.5473 mL	2.7365 mL	5.4730 mL
10 mM	0.2737 mL	1.3683 mL	2.7365 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.69 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.69 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.69 mM); Clear solution

* All of the co-solvents are available by MCE.