[CAS NO. 2300982-44-7] RIPK1-IN-7
PRODUCTS SPECIFICATIONS [2300982-44-7]
DESCRIPTION [2300982-44-7]
Overview
| MDL | MFCD32067925 |
|---|---|
| Molecular Weight | 481.47 |
| Molecular Formula | C25H22F3N5O2 |
| SMILES | NC1=C2C(N(CC)C=C2C3=CC(CCN4C(CC5=CC=CC(OC(F)(F)F)=C5)=O)=C4C=C3)=NC=N1 |
Summary
In Vitro
RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC
50
of 2nM
[1]
.
RIPK1-IN-7 displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC
50
s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 129.81 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0770 mL | 10.3849 mL | 20.7697 mL |
| 5 mM | 0.4154 mL | 2.0770 mL | 4.1539 mL |
| 10 mM | 0.2077 mL | 1.0385 mL | 2.0770 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.32 mM); Clear solution