[CAS NO. 2304448-00-6] Antibacterial agent 124

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PRODUCTS SPECIFICATIONS [2304448-00-6]

Catalog

HY-151880

Brand

MCE

CAS

2304448-00-6

DESCRIPTION [2304448-00-6]

Overview

MDL	-
Molecular Weight	337.78
Molecular Formula	C16H17ClFN3O2
SMILES	O=C(CN1C=NC2=CC(Cl)=C(C=C2C1=O)F)C[C@@H]3CCCCN3

For research use only. We do not sell to patients.

Summary

Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC ₅₀ of 0.18 μM against Staphylococcus aureus ProRS ( Sa ProRS) ^[1] .

IC50 & Target

IC50: 0.18 μM ( Sa ProRS) ^[1]
Kd: 30.3 nM ( Sa ProRS) ^[1]

In Vitro

Antibacterial agent 124 (Compound 3) shows antibacterial activity with MICs of 1, 1, 4, 1, 1, 2 and 4 μg/mL against E. coli (ATCC25922), S. flexneri (CMCC51572), S. typhi (CMCC50094), MRSA252 , MRSA R3708 , S. aureus ATCC29213, S. aureus ATCC25923, respectively. And the CC ₅₀ to HepG2 is 4.32 μM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Cheng B, et al. Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. J Med Chem. 2022 Nov 17.