[CAS NO. 2321337-71-5]  Protein kinase inhibitor 1 hydrochloride

Protein kinase inhibitor 1 hydrochloride is a potent HIPK2 inhibitor, with IC ₅₀ s of 136 and 74 nM for HIPK1 and HIPK2, and a K _d of 9.5 nM for HIPK2. Protein kinase inhibitor 1 (Compound A64) is not an effective Cdk1 inhibitor (IC ₅₀ > 10 μM). A64 is moderately selective across a panel of kinases, with K _d s of 3.7 nM (PIM3), 6.1 nM (CSNK2A2), 6.1 nM (CSNK2A2), 8.8 nM (DYRK1A), 9.5 nM (DAPK1), 31 nM (CSNK2A1), 37 nM (PIM1), 130 nM (DRAK2), 150 nM (CLK2), 190 nM (DRAK1), 220 nM (ULK2), 240 nM (CLK1), 250 nM (DYRK2), and 390 nM (ERK8) and IC ₅₀ s of 19 nM (DYRK1A), 62 nM (DYRK1B), and 74 nM (HIPK2) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.