[CAS NO. 2322245-49-6] SRI-37330hydrochloride

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PRODUCTS SPECIFICATIONS [2322245-49-6]

Catelog

HY-141623

Brand

MCE

CAS

2322245-49-6

DESCRIPTION [2322245-49-6]

Overview

MDL	-
Molecular Weight	424.87
Molecular Formula	C16H20ClF3N4O2S
SMILES	O=S(NCC1CN(CCC1)C2=C3C=C(C(F)(F)F)C=CC3=NC=N2)(C)=O.Cl

For research use only. We do not sell to patients.

Summary

SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research ^[1] .

IC50 & Target

TXNIP ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL ( 147.10 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3537 mL	11.7683 mL	23.5366 mL
5 mM	0.4707 mL	2.3537 mL	4.7073 mL
10 mM	0.2354 mL	1.1768 mL	2.3537 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Thielen LA, et al. Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action. Cell Metab. 2020 Sep 1;32(3):353-365.e8.