[CAS NO. 23282-20-4] Nivalenol
PRODUCTS SPECIFICATIONS [23282-20-4]
DESCRIPTION [23282-20-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 312.32 |
| Molecular Formula | C15H20O7 |
| SMILES | CC12C3(CO3)[C@@](O[C@@]4([H])[C@]2(CO)[C@@H](C(C(C)=C4)=O)O)([H])[C@H](O)[C@H]1O |
Summary
Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum , is a fungal metabolite present in agricultural product [1] . Nivalenol induces cell death through caspase -dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect [2] .
IC50 & Target
|
Caspase |
Appearance
Solid
Source
Fusarium graminearum
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 160.09 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2018 mL | 16.0092 mL | 32.0184 mL |
| 5 mM | 0.6404 mL | 3.2018 mL | 6.4037 mL |
| 10 mM | 0.3202 mL | 1.6009 mL | 3.2018 mL |
References
- [1] Bryła M, et al. Natural Occurrence of Nivalenol, Deoxynivalenol, and Deoxynivalenol-3-Glucoside in Polish Winter Wheat. Toxins (Basel). 2018 Feb 13;10(2).
- [2] Aupanun S, et al. Individual and combined mycotoxins deoxynivalenol, nivalenol, and fusarenon-X induced apoptosis in lymphoid tissues of mice after oral exposure. Toxicon. 2019 Jul;165:83-94.
Synonyms