[CAS NO. 2361327-08-2] DS44960156

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PRODUCTS SPECIFICATIONS [2361327-08-2]

Catalog

HY-131943

Brand

MCE

CAS

2361327-08-2

DESCRIPTION [2361327-08-2]

Overview

MDL	-
Molecular Weight	349.34
Molecular Formula	C20H15NO5
SMILES	O=C(O)C1=CC=C(C(N2CCC(C3=CC=CC=C3O4)=C(C4=O)C2)=O)C=C1

For research use only. We do not sell to patients.

Summary

DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC ₅₀ values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively ^[1] .

IC50 & Target

IC50: 1.6 μM (MTHFD2), >30 μM (MTHFD1) ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

References

[1] Junya Kawai, et al. Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold. ACS Med Chem Lett. 2019 May 24;10(6):893-898.