[CAS NO. 2365172-82-1] DesmorpholinylNavitoclax-NH-Me

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PRODUCTS SPECIFICATIONS [2365172-82-1]

Catalog

HY-131232

Brand

MCE

CAS

2365172-82-1

DESCRIPTION [2365172-82-1]

Overview

MDL	-
Molecular Weight	918.55
Molecular Formula	C44H51ClF3N5O5S3
SMILES	O=C(C1=CC=C(N2CCN(CC3=C(C4=CC=C(Cl)C=C4)CCC(C)(C)C3)CC2)C=C1)NS(C5=CC(S(=O)(C(F)(F)F)=O)=C(N[C@@H](CSC6=CC=CC=C6)CCNC)C=C5)(=O)=O

For research use only. We do not sell to patients.

Summary

Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 (HY-133557) ^[1] ^[2] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 108.87 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0887 mL	5.4434 mL	10.8867 mL
5 mM	0.2177 mL	1.0887 mL	2.1773 mL
10 mM	0.1089 mL	0.5443 mL	1.0887 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (2.72 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (2.72 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (2.72 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Guangrong Zheng, et al. Agents de dégradation de protéines bcl-2 pour le traitement du cancer. WO2019144117A1.