[CAS NO. 2375846-41-4] DVD-445
PRODUCTS SPECIFICATIONS [2375846-41-4]
DESCRIPTION [2375846-41-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 458.50 |
| Molecular Formula | C25H28F2N2O4 |
| SMILES | O=C(OCCN(C(C1=CC=C(F)C=C1)C(NC(C)(C)C)=O)C)/C=C/C(C2=CC=C(F)C=C2)=O |
Summary
DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC 50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application [1] .
IC50 & Target
IC50: 0.60 μM (rat TrxR1) [1]
In Vitro
DVD-445 (Compound 7) shows a cytotoxic effect in SH-SY5Y, U87, HaCaT cell lines and PBMCs with IC 50 s of 10.99 μM, 9.70 μM, 8.30 μM, 55.71 μM, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 218.10 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1810 mL | 10.9051 mL | 21.8103 mL |
| 5 mM | 0.4362 mL | 2.1810 mL | 4.3621 mL |
| 10 mM | 0.2181 mL | 1.0905 mL | 2.1810 mL |