[CAS NO. 2376580-08-2] SU056

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Catalog:	HY-150231
Brand:	MCE
CAS:	2376580-08-2

Overview

MDL	-
Molecular Weight	369.34
Molecular Formula	C20H16FNO5
SMILES	O=C1OCC2=C1C(C3=CC4=C(C=C3N2CCO)OCO4)C5=CC(F)=CC=C5

For research use only. We do not sell to patients.

Summary

SU056 is a YB-1 inhibitor. SU056 induces cell-cycle arrest, apoptosis , and inhibits cell migration in ovarian cancer cells. SU056 interacts with YB-1 and inhibits and its associated downstream proteins and pathways. SU056 can enhance the cytotoxic effects of Paclitaxel (HY-B0015) ^[1] .

IC50 & Target

YB-1 ^[1]

In Vitro

SU056 (0-10 μM approximately, 48 h) inhibits cell growth in OVCAR3/4/5/8, SKOV3 and ID8 cells ^[1] 。
SU056 (1 μM, 5-8 days) inhibits colony formation in a dose-dependent manner in OVCAR-8 and ID8 cells ^[1] 。
SU056 (1-5 μM, 6 h) arrests OVCAR8, SKOV3, and ID8 cells in the sub-G1 and G1 phases ^[1] .
SU056 (0-1 μM, 12 h) inhibits cell migration in OVCAR8, SKOV3, and ID8 cells ^[1] .
SU056 (0-5 μM, 24 h) induces apoptotic cell death in OVCAR8, SKOV3, and ID8 cells ^[1] .
SU056 (1-5 μM, 12 h) inhibited the expression of YB-1, TMSB10, SUMO2, and PMSB2 proteins in OVCAR8 cells ^[1] .
SU056 (0.1, 0.5, and 1 μM, 48 h) enhances the cytotoxic effects of Paclitaxel (HY-B0015) (0.1, 0.5, and 1 nM) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[1]

Cell Line:	OVCAR3/4/5/8, SKOV3 and ID8 cells
Concentration:	0-10 μM approximately
Incubation Time:	48 h
Result:	Inhibited cell growth with IC ₅₀ values of 1.27, 6.8, 4.33, 3.18, 1.73, 3.75 μM.

Cell Migration Assay ^[1]

Cell Line:	OVCAR8, SKOV3, and ID8 cells
Concentration:	0, 0.5, 1 μM
Incubation Time:	12 h
Result:	Dose-dependently inhibited cell migration.

Western Blot Analysis ^[1]

Cell Line:	OVCAR8 cell
Concentration:	1-5 μM
Incubation Time:	12 h
Result:	Dose-dependently inhibited the YB-1, TMSB10, SUMO2, and PMSB2 proteins.

In Vivo

SU056 (20 mg/kg, i.p.) inhibits tumor growth in mice implanted with ID8 cells ^[1] .
SU056 (10 mg/kg, i.p., daily) combined with Paclitaxel (HY-B0015) (5 mg/kg, weekly, i.p.) shows a much greater reduction in OC tumor growth in immunodeficiency mice implanted with OVCAR8 OC tumors ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice implanted (s.c.) with luciferase-expressing ID8 cells ^[1]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced the tumor weight by 2-fold, and is well-tolerated. Reduced the lung metastases. Inhibited YB-1 expression and downstream MDR1 (IHC assay of tumor sample).

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Tailor D, et al. Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer. Cell Chem Biol. 2021 Aug 19;28(8):1206-1220.e6.

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