[CAS NO. 2376687-49-7] UCK2 Inhibitor-3
PRODUCTS SPECIFICATIONS [2376687-49-7]
DESCRIPTION [2376687-49-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 474.31 |
| Molecular Formula | C19H13BrFN5O2S |
| SMILES | O=C(NC1=CC=C(Br)C=C1)CSC(N=C2C3=CNN2C4=CC=C(F)C=C4)=NC3=O |
Summary
UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 ( UCK2 , a pyrimidine salvage enzyme) with an IC 50 value of 16.6 μM. UCK2 can replace dihydroorotate dehydrogenase ( DHODH ), in a certain extent, in infected or rapidly dividing cells to continue efficient uridine salvage. UCK2 Inhibitor-3 also inhibits DNA polymerase eta and kappa with IC 50 s of 56 μM and 16 μM [1] .
IC50 & Target
IC50: 16.6 μM (UCK2); 56 μM (DNA polymerase η); 16 μM (DNA polymerase κ) [1]
In Vitro
Dihydroorotate dehydrogenase (DHODH), a rate-limiting enzyme in mammalian de novo pyrimidine synthesis. UCK2 can make up for DHODH in a certain extent, in infected or rapidly dividing cells for uridine salvage. DHODH inhibition has antiviral and anticancer significance, while UCK2 Inhibitor-3 suppress nucleoside salvage in cells both in the presence and absence of DHODH inhibitors
[1]
.
UCK2 Inhibitor-3 (compound 135416439) is an inhibitor against pyrimidine salvage enzyme, non-competitive with Uridine and ATP with K
i
values of 13 μM and 12 μM, respectively
[1]
.
UCK2 Inhibitor-3 (50 μM) inhibits UCK2 with inhibition rate of 31.3%
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.