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Catalog: | HY-153012 |
Brand: | MCE |
CAS: | 2394874-60-1 |
MDL | - |
---|---|
Molecular Weight | 531.48 |
Molecular Formula | C25H24F3N5O5 |
SMILES | O=C(C1=NN(CC)C(C)=C1OCC(F)(F)F)NC2=NC=C(C=C2)OC3=C4C=C(OC)C(OC)=CC4=NC=C3 |
Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase ( Axl/Mer RTK ) and CSF1R inhibitor with K d s of <0.1 μM [1] .
Kd: <0.1 μM (Axl, Mer, CSF1R) [1]
Axl/Mer-IN-1 (Compound 1) inhibits cellular Axl activity with an IC 50 of <0.5 μM by H1299 Elisa assay. Axl/Mer-IN-1 inhibits cellular CSF1R activity with IC 50 s of <0.5 μM and <1.0 μM by THP-1 Elisa assay and by M-NFS-60 viability assay, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Room temperature in continental US; may vary elsewhere.
Please store the product under the recommended conditions in the Certificate of Analysis.
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