[CAS NO. 2411088-26-9]  CC260

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PRODUCTS SPECIFICATIONS [2411088-26-9]

Catalog
HY-139188
Brand
MCE
CAS
2411088-26-9

DESCRIPTION [2411088-26-9]

Overview

MDL-
Molecular Weight490.43
Molecular FormulaC24H29Cl2N5O2
SMILESCN(C1=O)C(C(N(C2CCCC2)[C@@H]1CC3CCCC3)=N4)=CN=C4NC5=CC(Cl)=C(C(Cl)=C5)O

For research use only. We do not sell to patients.

Summary

CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with K i s of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2 . CC260 can be used for cell energy metabolism, diabetes and cancer research [1] .


IC50 & Target

Ki: 40 nM (PI5P4Kα) and 30 nM (PI5P4Kβ) [1]


In Vitro

In cultured C2C12 myotubes, CC260 (20 μM) enhances Insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 but suppresses S6K phosphorylation (Thr-389) by mTORC1 [1] .
CC260 (2.5 μM, 5 μM, 10 μM, 20 μM) significantly increases phosphorylation of acetyl-CoA carboxylase (ACC) in a dose-dependent manner [1] .
CC260 treatment reduces the ability of BT474 cells to survive serum starvation, which could be rescued by expressing the PI5P4Kβ refractory mutant [1] .
In BT474 cells, CC260 treatment causes an increase in glycolytic ATP production [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 160 mg/mL ( 326.24 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0390 mL 10.1951 mL 20.3903 mL
5 mM 0.4078 mL 2.0390 mL 4.0781 mL
10 mM 0.2039 mL 1.0195 mL 2.0390 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: 4 mg/mL (8.16 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 4 mg/mL (8.16 mM); Clear solution

* All of the co-solvents are available by MCE.