[CAS NO. 2411088-26-9] CC260

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Catalog:	HY-139188
Brand:	MCE
CAS:	2411088-26-9

Overview

MDL	-
Molecular Weight	490.43
Molecular Formula	C24H29Cl2N5O2
SMILES	CN(C1=O)C(C(N(C2CCCC2)[C@@H]1CC3CCCC3)=N4)=CN=C4NC5=CC(Cl)=C(C(Cl)=C5)O

For research use only. We do not sell to patients.

Summary

CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with K _i s of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2 . CC260 can be used for cell energy metabolism, diabetes and cancer research ^[1] .

IC50 & Target

Ki: 40 nM (PI5P4Kα) and 30 nM (PI5P4Kβ) ^[1]

In Vitro

In cultured C2C12 myotubes, CC260 (20 μM) enhances Insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 but suppresses S6K phosphorylation (Thr-389) by mTORC1 ^[1] .
CC260 (2.5 μM, 5 μM, 10 μM, 20 μM) significantly increases phosphorylation of acetyl-CoA carboxylase (ACC) in a dose-dependent manner ^[1] .
CC260 treatment reduces the ability of BT474 cells to survive serum starvation, which could be rescued by expressing the PI5P4Kβ refractory mutant ^[1] .
In BT474 cells, CC260 treatment causes an increase in glycolytic ATP production ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 160 mg/mL ( 326.24 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0390 mL	10.1951 mL	20.3903 mL
5 mM	0.4078 mL	2.0390 mL	4.0781 mL
10 mM	0.2039 mL	1.0195 mL	2.0390 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 4 mg/mL (8.16 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 4 mg/mL (8.16 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Song Chen, et al. Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2002486118.

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