MDL | - |
---|---|
Molecular Weight | 490.43 |
Molecular Formula | C24H29Cl2N5O2 |
SMILES | CN(C1=O)C(C(N(C2CCCC2)[C@@H]1CC3CCCC3)=N4)=CN=C4NC5=CC(Cl)=C(C(Cl)=C5)O |
Ki: 40 nM (PI5P4Kα) and 30 nM (PI5P4Kβ) [1]
In cultured C2C12 myotubes, CC260 (20 μM) enhances Insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 but suppresses S6K phosphorylation (Thr-389) by mTORC1
[1]
.
CC260 (2.5 μM, 5 μM, 10 μM, 20 μM) significantly increases phosphorylation of acetyl-CoA carboxylase (ACC) in a dose-dependent manner
[1]
.
CC260 treatment reduces the ability of BT474 cells to survive serum starvation, which could be rescued by expressing the PI5P4Kβ refractory mutant
[1]
.
In BT474 cells, CC260 treatment causes an increase in glycolytic ATP production
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Solid
Room temperature in continental US; may vary elsewhere.
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
DMSO : 160 mg/mL ( 326.24 mM ; Need ultrasonic)
Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
---|
1 mM | 2.0390 mL | 10.1951 mL | 20.3903 mL |
5 mM | 0.4078 mL | 2.0390 mL | 4.0781 mL |
10 mM | 0.2039 mL | 1.0195 mL | 2.0390 mL |