[CAS NO. 2413192-59-1]  HBV-IN-29

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PRODUCTS SPECIFICATIONS [2413192-59-1]

Catelog
HY-148780
Brand
MCE
CAS
2413192-59-1

DESCRIPTION [2413192-59-1]

Overview

MDL-
Molecular Weight414.84
Molecular FormulaC22H19ClO6
SMILESO=C(O)COC1CC(COC2=CC=C(C3=CC(C4=CC=CC(Cl)=C4O3)=O)C=C2)C1

For research use only. We do not sell to patients.

Summary

HBV-IN-29 (ex8), a flavone derivative, is a potent covalently closed circular DNA (cccDNA) inhibitor. cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-29 has the potential for the research of HBV infection [1] .


In Vitro

HBV-IN-29 (ex8; 24 h) inhibits HBeAg levels and cell viability with an IC 50 value of 1.34 μM in HepDES19 cells. HepDES19 is the cell line that produces cccDNA [1] .
HBV-IN-29 (5 days) decreases cccDNA levels in HepDES19 cells in a dose-dependent manner [1] .
HBV-IN-29 (9 days; primary human hepatocyte (PHH)) has anti-HBV effect and inhibits HBeAg with an IC 50 value of 0.12 μM [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.