[CAS NO. 2413192-92-2]  HBV-IN-30

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PRODUCTS SPECIFICATIONS [2413192-92-2]

Catalog
HY-148781
Brand
MCE
CAS
2413192-92-2

DESCRIPTION [2413192-92-2]

Overview

MDL-
Molecular Weight493.73
Molecular FormulaC22H18BrClO6
SMILESClC1=C2C(C(C=C(C3=CC(Br)=C(C=C3)OCCO[C@@H]4C[C@@H](C4)C(O)=O)O2)=O)=CC=C1

For research use only. We do not sell to patients.

Summary

HBV-IN-30 (ex44), a flavone derivative, is a potent covalently closed circular DNA (cccDNA) inhibitor. cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-30 has the potential for the research of HBV infection [1] .


In Vitro

HBV-IN-30 (ex44; 24 h) inhibits HBeAg levels and cell viability with an IC 50 value of 0.57 μM in HepDES19 cells. HepDES19 is the cell line that produces cccDNA [1] .
HBV-IN-30 (5 days) decreases cccDNA levels in HepDES19 cells in a dose-dependent manner [1] .
HBV-IN-30 (9 days; primary human hepatocyte (PHH)) has anti-HBV effect and inhibits HBeAg with an IC 50 value of 0.04 μM [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.