[CAS NO. 2415-24-9] Catalpol

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PRODUCTS SPECIFICATIONS [2415-24-9]

Catalog

HY-N0820

Brand

MCE

CAS

2415-24-9

DESCRIPTION [2415-24-9]

Overview

MDL	MFCD00066264
Molecular Weight	362.33
Molecular Formula	C15H22O10
SMILES	OC[C@@]12[C@]([C@@H]3O[C@]([C@@H]([C@@H](O)[C@@H]4O)O)([H])O[C@@H]4CO)([H])[C@](C=CO3)([H])[C@H](O)[C@@H]1O2

For research use only. We do not sell to patients.

6 Publications Citing Use of MCE

Summary

Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa . Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti- HBV effects ^[1] ^[2] ^[3] .

In Vitro

Catalpol (0.1 μg/mL; for 3 days) can induce neuronal differentiation in PC12 cells through activation of the intracellular signal transduction pathway, and promote neurite length ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Catalpol (25-100 mg/kg; intraperitoneal injection; once) treatment clearly reduces blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal ischemia/reperfusion-injury (IRI) mice. Catalpol markedly reduces the expression of PI3K, Akt and eNOS levels, and suppresses the TNF-α, IL-1β, IL-6 and IL-10 activities ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice treated with renal ischemia/reperfusion surgery ^[1]
Dosage:	25 mg/kg, 50 mg/kg and 100 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Clearly reduced blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal IRI mice.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 30 mg/mL ( 82.80 mM )

H ₂ O : 7.14 mg/mL ( 19.71 mM ; ultrasonic and warming and heat to 60°C)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7599 mL	13.7996 mL	27.5992 mL
5 mM	0.5520 mL	2.7599 mL	5.5198 mL
10 mM	0.2760 mL	1.3800 mL	2.7599 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.74 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.74 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.74 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl

Catalpol

β-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, [1aS-(1aα,1bβ,2β,5aβ,6β,6aα)]-

(1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl β-D-glucopyranoside

Catalpinoside

De(p-hydroxybenzoyl)catalposide

Catapol

Aucubin 7,8-epoxide

7,8-Epoxyaucubin