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[CAS NO. 2415-24-9] Catalpol
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N0820 |
| Brand: | MCE |
| CAS: | 2415-24-9 |
Overview
| MDL | MFCD00066264 |
|---|---|
| Molecular Weight | 362.33 |
| Molecular Formula | C15H22O10 |
| SMILES | OC[C@@]12[C@]([C@@H]3O[C@]([C@@H]([C@@H](O)[C@@H]4O)O)([H])O[C@@H]4CO)([H])[C@](C=CO3)([H])[C@H](O)[C@@H]1O2 |
6 Publications Citing Use of MCE
Summary
In Vitro
Catalpol (0.1 μg/mL; for 3 days) can induce neuronal differentiation in PC12 cells through activation of the intracellular signal transduction pathway, and promote neurite length [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Catalpol (25-100 mg/kg; intraperitoneal injection; once) treatment clearly reduces blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal ischemia/reperfusion-injury (IRI) mice. Catalpol markedly reduces the expression of PI3K, Akt and eNOS levels, and suppresses the TNF-α, IL-1β, IL-6 and IL-10 activities [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | C57BL/6 mice treated with renal ischemia/reperfusion surgery [1] |
| Dosage: | 25 mg/kg, 50 mg/kg and 100 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | Clearly reduced blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal IRI mice. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 30 mg/mL ( 82.80 mM )
H 2 O : 7.14 mg/mL ( 19.71 mM ; ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7599 mL | 13.7996 mL | 27.5992 mL |
| 5 mM | 0.5520 mL | 2.7599 mL | 5.5198 mL |
| 10 mM | 0.2760 mL | 1.3800 mL | 2.7599 mL |
References
- [1] Jili Zhu, et al. Catalpol protects mice against renal ischemia/reperfusion injury via suppressing PI3K/Akt-eNOS signaling and inflammation. Int J Clin Exp Med. 2015 Feb 15;8(2):2038-44.
- [2] M Yamazaki, et al. Neuritogenic effect of natural iridoid compounds on PC12h cells and its possible relation to signaling protein kinases. Biol Pharm Bull. 1996 Jun;19(6):791-5.
- [3] R Mehrotra, et al. In vitro studies on the effect of certain natural products against hepatitis B virus. Indian J Med Res. 1990 Apr;92:133-8.
Synonyms
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